|
1）Kronenberg M, Rudensky A. Regulation of immunity by self-reactive T cells. Nature. 2005; 435: 598-604
|
|
|
|
2）Rathmell JC, Thompson CB. Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell. 2002; 109 Suppl: S97-107
|
|
|
|
|
|
3）Starr TK, Jameson SC, Hogquist KA. Positive and negative selection of T cells. Annu Rev Immunol. 2003; 21: 139-76
|
|
|
|
|
|
4）Hershko A, Ciechanover A. The ubiquitin system. Annu Rev Biochem. 1998; 67: 425-79
|
|
|
|
|
|
5）Yokouchi M, Kondo T, Houghton A, et al. Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. J Biol Chem. 1999; 274: 31707-12
|
|
|
|
|
|
6）Boussiotis VA, Freeman GJ, Berezovskaya A, et al. Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science. 1997; 278: 124-8
|
|
|
|
|
|
7）Heissmeyer V, Macian F, Im SH, et al. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol. 2004; 5: 255-65
|
|
|
|
|
|
8）Jeon MS, Atfield A, Venuprasad K, et al. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity. 2004; 21: 167-77
|
|
|
|
|
|
9）Safford M, Collins S, Lutz MA, et al. Egr-2 and Egr-3 are negative regulators of T cell activation. Nat Immunol. 2005; 6: 472-80
|
|
|
|
|
|
10）Keane MM, Ettenberg SA, Nau MM, et al. cbl-3: a new mammalian cbl family protein. Oncogene. 1999; 18: 3365-75
|
|
|
|
|
|
11）Wang HY, Altman Y, Fang D, et al. Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70. J Biol Chem. 2001; 276: 26004-11
|
|
|
|
|
|
12）Naramura M, Jang IK, Kole H, et al. c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nat Immunol. 2002; 3: 1192-9
|
|
|
|
|
|
13）Chiang YJ, Kole HK, Brown K, et al. Cbl-b regulates the CD28 dependence of T-cell activation. Nature. 2000; 403: 216-20
|
|
|
|
|
|
14）Murphy MA, Schnall RG, Venter DJ, et al. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol Cell Biol. 1998; 18: 4872-82
|
|
|
|
|
|
15）Naramura M, Kole HK, Hu RJ, et al. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc Natl Acad Sci USA. 1998; 95: 15547-52
|
|
|
|
|
|
16）Thien CB, Blystad FD, Zhan Y, et al. Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. EMBO J. 2005; 24: 3807-19
|
|
|
|
|
|
17）Bachmaier K, Krawczyk C, Kozieradzki I, et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000; 403: 211-6
|
|
|
|
|
|
18）Yokoi N, Komeda K, Wang HY, et al. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet. 2002; 31: 391-4
|
|
|
|
|
|
19）Li D, Gal I, Vermes C, et al. Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. J Immunol. 2004; 173: 7135-9
|
|
|
|
|
|
20）Zhang J, Bardos T, Li D, et al. Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination. J Immunol. 2002; 169: 2236-40
|
|
|
|
|
|
21）Huang F, Kitaura Y, Jang I, et al. Establishment of the major compatibility complex-dependent development of CD4＋ and CD8＋ T cells by the Cbl family proteins. Immunity. 2006; 25: 571-81
|
|
|
|
|
|
22）Anandasabapathy N, Ford GS, Bloom D, et al. GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4＋ T cells. Immunity. 2003; 18: 535-47
|
|
|
|
|
|
23）Soares L, Seroogy C, Skrenta H, et al. Two isoforms of otubain 1 regulate T cell anergy via GRAIL. Nat Immunol. 2004; 5: 45-54
|
|
|
|
|
|
24）Su L, Lineberry N, Huh Y, et al. A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes. J Immunol. 2006; 177: 7559-66
|
|
|
|
|
|
25）MacKenzie DA, Schartner J, Lin J, et al. GRAIL is up-regulated in CD4＋ CD25＋ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype. J Biol Chem. 2007; 282: 9696-702
|
|
|
|
|
|
26）Macian F, Garcia-Cozar F, Im SH, et al. Transcriptional mechanisms underlying lymphocyte tolerance. Cell. 2002; 109: 719-31
|
|
|
|
|
|
27）Angers A, Ramjaun AR, McPherson PS. The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system. J Biol Chem. 2004; 279: 11471-9
|
|
|
|
|
|
28）Qiu L, Joazeiro C, Fang N, et al. Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase. J Biol chem. 2000; 275: 35734-7
|
|
|
|
|
|
29）Fang D, Elly C, Gao B, et al. Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. Nat Immunol. 2002; 3: 281-7
|
|
|
|
|
|
30）Mondino A, Whaley CD, DeSilva DR, et al. Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells. J Immunol. 1996; 157: 2048-57
|
|
|
|
|
|
31）Gao M, Labuda T, Xia Y, et al. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science. 2004; 306: 271-5
|
|
|
|
|
|
32）Gallagher E, Gao M, Liu YC, et al. Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc Natl Acad Sci USA. 2006; 103: 1717-22
|
|
|
|
|
|
33）Yang C, Zhou W, Jeon MS, et al. Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation. Mol Cell. 2006; 21: 135-41
|
|
|
|
|
|
34）Venuprasad K, Elly C, Gao M, et al. Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. J Clin Invest. 2006; 116: 1117-26
|
|
|
|
|
|
35）Cristillo AD, Nie L, Macri MJ, et al. Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes. J Biol Chem. 2003; 278: 34587-97
|
|
|
|
|
|
36）Harvey KF, Shearwin-Whyatt LM, Fotia A, et al. N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J Biol Chem. 2002; 277: 9307-17
|
|
|
|
|
|
37）Oliver PM, Cao X, Worthen GS, et al. Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity. 2006; 25: 929-40
|
|
|
|
|
|
38）Kitaura Y, Jang IK, Wang Y, et al. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity. 2007; 26: 567-78
|
|
|
|
|