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1)Laughlin MJ, Eapen M, Rubinstein P, et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med. 2004; 351: 2265-75
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2)Rocha V, Labopin M, Sanz G, et al. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med. 2004; 351: 2276-85
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3)Takahashi S, Iseki T, Ooi J, et al. Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies. Blood. 2004; 104: 3813-20
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4)Wang J, Kimura T, Asada R, et al. SCID-repopulating cell activity of human cord blood-derived CD34- cells assured by intra-bone marrow injection. Blood. 2003; 101: 2924-31
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5)Castello S, Podesta M, Menditto VG, et al. Intra-bone marrow injection of bone marrow and cord blood cells: an alternative way of transplantation associated with a higher seeding efficiency. Exp Hematol. 2004; 32: 782-7
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6)Brunstein CG, Barker JN, Weisdorf DJ, et al. Intra-BM injection to enhance engraftment after myeloablative umbilical cord blood trans-plantation with two partially HLA-matched units. Bone Marrow Transplant. 2009; 43: 935-40
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7)Okada M, Yoshihara S, Taniguchi K, et al. Intrabone marrow transplantation of unwashed cord blood using reduced-intensity conditioning treatment: A phase I study. Biol Blood Marrow Transplant. 2012; 18: 633-9
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8)van der Loo JC, Ploemacher RE. Marrow- and spleen-seeding efficiencies of all murine hematopoietic stem cell subsets are decreased by preincubation with hematopoietic growth factors. Blood. 1995; 85: 2598-606
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9)van Hennik PB, de Koning AE, Ploemacher RE. Seeding efficiency of primitive human hemato-poietic cells in nonobese diabetic/severe com-bined immune deficiency mice: implications for stem cell frequency assessment. Blood. 1999; 94: 3055-61
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10)Cashman JD, Eaves CJ. High marrow seeding efficiency of human lymphomyeloid repopulating cells in irradiated NOD/SCID mice. Blood. 2000; 96: 3979-81
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11)Ikehara S. New strategies for BMT, organ trans-plantation, and regeneration therapy. Hematology. 2003; 8: 77-81
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12)Kushida T, Inaba M, Hisha H, et al. Intra-bone marrow injection of allogeneic bone marrow cells: A powerful new strategy for treatment of intractable autoimmune diseases in MRL/lpr mice. Blood 2001; 97: 3292-9
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13)Nakamura K, Inaba M, Sugiura K, et al. Enhancement of allogeneic hematopoietic stem cell engraftment and prevention of GVHD by intra-bone marrow-bone marrow transplantation plus donor lymphocyte infusion. Stem Cells. 2004; 22: 125-34
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14)Zhang Y, Adachi Y, Suzuki Y, et al. Simultaneous injection of bone marrow cells and stromal cells into bone marrow accelerates hematopoiesis in vivo. Stem Cells. 2004; 22: 1256-62
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15)Baba S, Inaba M, Iwai H, et al. Intra-bone marrow-bone marrow transplantation facilitates hemopoietic recovery including dendritic cells. Immunobiology. 2005; 210: 33-42
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16)Wang J, Kimura T, Asada R, et al. SCID-repopulating cell activity of human cord blood-derived CD-34 cells assured by intra-bone marrow injection. Blood. 2003; 101: 2924-31
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17)Kimura T, Wang J, Matsui K, et al. Proliferative and migratory potentials of human cord blood-derived CD34- severe combined immuno-deficiency repopulating cells that retain secondary reconstituting capacity. Int J Hematol. 2004; 79: 328-33
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18)Feng Q, Chow PK, Frassoni F, et al. Nonhuman primate allogeneic hematopoietic stem cell transplantation by intraosseus vs intravenous injection: Engraftment, donor cell distribution, and mechanistic basis. Exp Hematol. 2008; 36: 1556-66
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19)Massollo M, Podestà M, Marini C, et al. Contact with the bone marrow microenvironment readdresses the fate of transplanted hemato-poietic stem cells. Exp Hematol. 2010; 38: 968-77
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20)Hagglund H, Ringden O, Agren B, et al. Intraosseous compared to intravenous infusion of allogeneic bone marrow. Bone Marrow Transplant. 1998; 21: 331-5
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21)Yano M, Watanabe A, Kawano Y, et al. Facilitated engraftment by intramedullary administered enriched allogeneic CD34+ cells? Bone Marrow Transplant. 1999; 23: 847-8
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22)Li C, He Y, Feng X, et al. An innovative approach to bone marrow collection and transplantation in a patient with beta-thalassemia major: marrow collection using a perfusion method followed by intra-bone marrow injection of collected bone marrow cells. Int J Hematol. 2007; 85: 73-7
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23)Frassoni F, Gualandi F, Podesta M, et al. Direct intrabone transplant of unrelated cord blood cells in acute leukaemia: a phase I/II study. Lancet Oncol. 2008; 9: 831-9
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24)Frassoni, F, Varaldo R, Gualandi F, et al. The intra-bone marrow injection of cord blood cells extends the possibility of transplantation to the majority of patients with malignant hemato-poietic diseases. Best Pract Res Clin Haematol. 2010; 23: 237-44
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25)Chao NJ, Koh LP, Long GD, et al. Adult recipients of umbilical cord blood transplants after nonmyeloablative preparative regimens. Biol Blood Marrow Transplant. 2004; 10: 569-75
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26)Barker JN, Weisdorf DJ, DeFor TE, et al. Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning. Blood. 2003; 102: 1915-9
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27)Narimatsu H, Kami M, Miyakoshi S, et al. Graft failure following reduced-intensity cord blood transplantation for adult patients. Br J Haematol. 2006; 132: 36-41
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28)Misawa M, Kai S, Okada M, et al. Reduced-intensity conditioning followed by unrelated umbilical cord blood transplantation for advanced hematologic malignancies: rapid engraftment in bone marrow. Int J Hematol. 2006; 83: 74-9
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