文献リスト

1）Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer. 2006; 6(5): 392-401

2）Orimo A, Weinberg RA. Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle. 2006; 5(15): 1597-601

3）Räsänen K, Vaheri A. Activation of fibroblasts in cancer stroma. Exp Cell Res. 2010; 316(17): 2713-22

4）De Wever O, Demetter P, Mareel M, et al. Stro­mal myofibroblasts are drivers of invasive cancer growth. Int J Cancer. 2008; 123(10): 2229-38

5）Nyberg P, Salo T, Kalluri R. Tumor microenviron­ment and angiogenesis. Front Biosci. 2008; 13: 6537-53

6）Ishii G, Ito TK, Aoyagi K, et al. Presence of human circulating progenitor cells for cancer stromal fibroblasts in the blood of lung cancer patients. Stem Cells. 2007; 25(6): 1469-77

7）Hoshino A, Chiba H, Nagai K, et al. Human vascular adventitial fibroblasts contain mesen­chymal stem/progenitor cells. Biochem Biophys Res Commun. 2008; 368(2): 305-10

8）Ostman A, Augsten M. Cancer-associated fibro­blasts and tumor growth--bystanders turning into key players. Curr Opin Genet Dev. 2009; 19(1): 67-73

9）Sato N, Maehara N, Goggins M. Gene expression profiling of tumor-stromal interactions between pancreatic cancer cells and stromal fibroblasts. Cancer Res. 2004; 64(19): 6950-6

10）Kessenbrock K, Plaks V, Werb Z. Matrix metallo­proteinases: regulators of the tumor micro­environ­ment. Cell. 2010; 141(1): 52-67

11）Stuelten CH, DaCosta Byfield S, Arany PR, et al. Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-beta. J Cell Sci. 2005; 118(Pt 10): 2143-53

12）Gaggioli C. Hooper S, Hidalgo-Carcedo C, et al. Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol. 2007; 9(12): 1392-400

13）Orimo A. Gupta PB, Sgroi DC, et al. Stromal fibro­blasts present in invasive human breast carcino­mas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 2005; 121(3): 335-48

14）Kojima Y, Acar A, Eaton EN, et al.　Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci U S A. 2010; 107(46): 20009-14

15）Bremnes RM, Dønnem T, Al-Saad S, et al. The role of tumor stroma in cancer progression and prognosis: emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer. J Thorac Oncol. 2011; 6(1): 209-17

16）Ishii G, Hashimoto H, Asada K, et al. Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells: a novel character of tumor educated fibro­blasts. Int J Oncol. 2010; 37(2): 317-25

17）Moinfar F, Man YG, Arnould L, et al. Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carci­noma: implications for tumorigenesis. Cancer Res. 2000; 60(9): 2562-6

18）Shimosato Y, Suzuki A, Hashimoto T, et al. Progno­stic implications of fibrotic focus(scar)in small peripheral lung cancers. Am J Surg Pathol. 1980; 4(4): 365-73

19）Noguchi M, Morikawa A, Kawasaki M, et al. Small adenocarcinoma of the lung. Histologic characteristics and prognosis. Cancer. 1995; 75(12): 2844-52

20）Colpaert CG, Vermeulen PB, Fox SB, et al. The presence of a fibrotic focus in invasive breast carcinoma correlates with the expression of carbonic anhydrase IX and is a marker of hypoxia and poor prognosis. Breast Cancer Res Treat. 2003; 81(2): 137-47

21）Nakao M, Ishii G, Nagai K, et al. Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adeno­carcinoma. Cancer. 2009; 115(12): 2732-43

22）Kawase A. Ishii G, Nagai K, et al. Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma. Int J Cancer. 2008; 123(5): 1053-9

23） Ito M, Ishii G, Nagai K, et al. Prognostic impact of cancer-associated stromal cells in stage I lung adenocarcinoma patients. Chest. 2012; 142(1): 151-8

24）Pula B, Jethon A, Piotrowska A, et al. Podoplanin expression by cancer-associated fibroblasts predicts poor outcome in invasive ductal breast carcinoma. Histopathology. 2011; 59(6): 1249-60

25）Schoppmann SF, Berghoff A, Dinhof C, et al. Podoplanin-expressing cancer-associated fibro­blasts are associated with poor prognosis in invasive breast cancer. Breast Cancer Res Treat. 2012; 134(1): 237-44

26）Neri S, Ishii G, Taira T, et al.　Recruitment of Podoplanin Positive Cancer-Associated Fibro­blasts in Metastatic Lymph Nodes Predicts Poor Prognosis in Pathological N2 Stage III Lung Adenocarcinoma. Ann Surg Oncol. 2012; 19(12): 3953-62

27）Hoshino A, Ishii G, Ito T, et al. Podoplanin-positive fibroblasts enhance lung adenocarci­noma tumor formation: podoplanin in fibroblast functions for tumor progression. Cancer Res. 2011; 71(14): 4769-79

28）Ito S, Ishii G, Hoshino A, et al. Tumor promoting effect of podoplanin-positive fibroblasts is mediated by enhanced RhoA activity. Biochem Biophys Res Commun. 2012; 422(1): 194-9

29）Vermeulen L, De Sousa E, Melo F, et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol. 2010; 12(5): 468-76

30）Wang W, Li Q, Yamada T, et al. Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyro­sine kinase inhibitors. Clin Cancer Res. 2009; 15(21): 6630-8

NPO医学中央雑誌刊行会 https://www.jamas.or.jp/ info@jamas.or.jp