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1)Badman MK, et al. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007; 5(6): 426-37
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2)Inagaki T, et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab. 2007; 5(6): 415-25
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3)Wang H, et al. Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes. Mol Cell Biol. 2008; 28(1): 188-200
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4)Dutchak PA, et al. Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones. Cell. 2012; 148(3): 556-67
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5)Yu J, et al. Growth hormone stimulates transcription of the fibroblast growth factor 21 gene in the liver through the signal transducer and activator of transcription 5. Endocrinology. 2012; 153(2): 750-8
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6)Uebanso T, et al. Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet. J Nutr Biochem. 2012; 23(7): 785-90
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7)Chartoumpekis DV, et al. Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice. Diabetes. 2011; 60(10): 2465-73
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8)Kharitonenkov A, et al. FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho. J Cell Physiol. 2008; 215(1): 1-7
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9)Ogawa Y, et al. BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci U S A. 2007; 104(18): 7432-7
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10)Suzuki M, et al. betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol. 2008; 22(4): 1006-14
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11)Kurosu H, et al. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem. 2007; 282(37): 26687-95
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12)Kharitonenkov A, et al. FGF-21 as a novel metabolic regulator. J Clin Invest. 2005; 115(6): 1627-35
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13)Inagaki T, et al. Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab. 2008; 8(1): 77-83
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14)Badman MK, et al. Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology. 2009; 150(11): 4931-40
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15)Coskun T, et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology. 2008; 149(12): 6018-27
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16)Xu J, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes. 2009; 58(1): 250-9
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17)Winegar DA, et al. Effects of fenofibrate on lipid parameters in obese rhesus monkeys. J Lipid Res. 2001; 42(10): 1543-51
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18)Kharitonenkov A, et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology. 2007; 148(2): 774-81
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19)Lundasen T, et al. PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 2007; 360(2): 437-40
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20)Oishi K, et al. PPARalpha deficiency augments a ketogenic diet-induced circadian PAI-1 expression possibly through PPARgamma activation in the liver. Biochem Biophys Res Commun. 2010; 401(2): 313-8
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21)Potthoff MJ, et al. FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A. 2009; 106(26): 10853-8
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22)Moyers JS, et al. Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling. J Cell Physiol. 2007; 210(1): 1-6
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23)Xu J, et al. Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects. Am J Physiol Endocrinol Metab. 2009; 297(5): E1105-14
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24)Chau MD, et al. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway. Proc Natl Acad Sci U S A. 2010; 107(28): 12553-8
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25)Wente W, et al. Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes. 2006; 55(9): 2470-8
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26)Berglund ED, et al. Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity. Endocrinol-ogy. 2009; 150(9): 4084-93
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27)Fisher FM, et al. Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes. 2010; 59(11): 2781-9
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