|
1）Sanke T, Bell GI, Sample C, et al. An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing. J Biol Chem. 1988; 263: 17243-6
|
|
|
|
2）Haataja L, Gurlo T, Huang CJ, et al. Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. Endocr Rev. 2008; 29: 303-16
|
|
|
|
|
3）Hiddinga HJ, Eberhardt NL. Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cells. Am J Pathol. 1999; 154: 1077-88
|
|
|
|
|
|
4）Sakagashira S, Hiddinga HJ, Tateishi K, et al. S20G mutant amylin exhibits increased in vitro amyloidogenicity and increased intracellular cytotoxicity compared to wild-type amylin. Am J Pathol. 2000; 157: 2101-9
|
|
|
|
|
|
5）Shigihara N, Fukunaka A, Hara A, et al. Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy. J Clin Invest. 2014; 124: 3634-44
|
|
|
|
|
|
6）Matveyenko AV, Butler PC. Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes. ILAR J. 2006; 473: 225-33
|
|
|
|
|
|
7）Janson J, Soeller WC, Roche PC, et al. Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide. Proc Natl Acad Sci U S A. 1996; 93: 7283-8
|
|
|
|
|
|
8）Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell. 2011; 147: 728-41
|
|
|
|
|
|
9）Ebato C, Uchida T, Arakawa M, et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab. 2008; 8: 325-32
|
|
|
|
|
|
10）Jung HS, Chung KW, Won Kim J, et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab. 2008; 8: 318-24
|
|
|
|
|
|
11）Fujitani Y, Ueno T, Watada H. Autophagy in health and disease. 4. The role of pancreatic beta-cell autophagy in health and diabetes. Am J Physiol Cell Physiol. 2010; 299: C1-6
|
|
|
|
|
|
12）Watada H, Fujitani Y. Autophagy in pancreatic β-cells and its implication in diabetes. Mol Endocrinol. 2015; 29: 338-48
|
|
|
|
|
|
13）Masini M, Bugliani M, Lupi R, et al. Autophagy in human type 2 diabetes pancreatic beta cells. Diabetologia. 2009; 52: 1083-6
|
|
|
|
|
|
14）Abe H, Uchida T, Hara A, et al. Exendin-4 improves beta-cell function in autophagy-deficient beta-cells. Endocrinology. 2013; 154: 4512-24
|
|
|
|
|
|
15）Morita S, Sakagashira S, Shimajiri Y, et al. Autophagy protects against human islet amyloid polypeptide-associated apoptosis. J Diabetes Investig. 2011; 2: 48-55
|
|
|
|
|
|
16）Hiddinga HJ, Sakagashira S, Ishigame M, et al. Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance. J Diabetes Investig. 2012; 3: 138-47
|
|
|
|
|
|
17）Rivera JF, Costes S, Gurlo T, et al. Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity. J Clin Invest. 2014; 124: 3489-500
|
|
|
|
|
|
18）Kim J, Cheon H, Jeong YT, et al. Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes. J Clin Invest. 2014; 124: 3311-24
|
|
|
|
|
|
19）Ferreira ST, Vieira MN, De Felice FG. Soluble protein oligomers as emerging toxins in Alzheimer?s and other amyloid diseases. IUBMB Life. 2007; 59: 332-45
|
|
|
|
|
|
20）Kayed R, Head E, Thompson JL, et al. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003; 300: 486-9
|
|
|
|
|
|
21）Gurlo T, Ryazantsev S, Huang CJ, et al. Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway. Am J Pathol. 2010; 176: 861-9
|
|
|
|
|